Asthma and obesity in children: current evidence and potential systems biology approaches.

Frey, Ulrich; Latzin, Philipp; Usemann, J; Maccora, J; Zumsteg, U; Kriemler, S (2015). Asthma and obesity in children: current evidence and potential systems biology approaches. Allergy, 70(1), pp. 26-40. Wiley-Blackwell 10.1111/all.12525

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Both obesity and asthma are highly prevalent, complex diseases modified by multiple factors. Genetic, developmental, lung mechanical, immunological and behavioural factors have all been suggested as playing a causal role between the two entities; however, their complex mechanistic interactions are still poorly understood and evidence of causality in children remains scant. Equally lacking is evidence of effective treatment strategies, despite the fact that imbalances at vulnerable phases in childhood can impact long-term health. This review is targeted at both clinicians frequently faced with the dilemma of how to investigate and treat the obese asthmatic child and researchers interested in the topic. Highlighting the breadth of the spectrum of factors involved, this review collates evidence regarding the investigation and treatment of asthma in obese children, particularly in comparison with current approaches in 'difficult-to-treat' childhood asthma. Finally, the authors propose hypotheses for future research from a systems-based perspective.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Pneumologie (Pädiatrie)

UniBE Contributor:

Frey, Ulrich and Latzin, Philipp

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0105-4538

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

André Schaller

Date Deposited:

13 Apr 2015 15:33

Last Modified:

07 Nov 2016 10:14

Publisher DOI:

10.1111/all.12525

PubMed ID:

25236686

Uncontrolled Keywords:

asthma; children; lung function; obesity; systems physiology

BORIS DOI:

10.7892/boris.66593

URI:

https://boris.unibe.ch/id/eprint/66593

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