Multiple breath washout is feasible in the clinical setting and detects abnormal lung function in infants and young children with cystic fibrosis.

Stahl, Mirjam; Joachim, Cornelia; Blessing, Kerstin; Hämmerling, Susanne; Sommerburg, Olaf; Latzin, Philipp; Mall, Marcus A (2014). Multiple breath washout is feasible in the clinical setting and detects abnormal lung function in infants and young children with cystic fibrosis. Respiration, 87(5), pp. 357-363. Karger 10.1159/000357075

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BACKGROUND Cystic fibrosis (CF) lung disease starts in the first months of life often before the onset of clinical symptoms. Multiple breath washout (MBW) detects abnormal lung function in infants and young children in the laboratory setting. OBJECTIVE The aim of this study was to determine the feasibility of MBW in 0- to 4-year-old children with CF and non-CF controls in the clinical setting. METHODS Fourteen children with CF (mean age 1.3 ± 1.0 years) and 26 age-matched non-CF controls were sedated with chloral hydrate and MBW was performed with sulfur hexafluoride. RESULTS MBW measurements were successful in 27 of 40 children (67.5%). The mean lung clearance index (LCI) was significantly higher in CF patients compared to non-CF controls (p = 0.006). Further, the frequency of elevated LCI (z-score >1.96) was significantly increased in CF patients compared to controls (p = 0.0003). CONCLUSIONS We conclude that MBW is feasible and sensitive to detect abnormal lung function in infants and young children with CF in the clinical setting.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Pneumologie (Pädiatrie)
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine

UniBE Contributor:

Latzin, Philipp

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0025-7931

Publisher:

Karger

Language:

English

Submitter:

André Schaller

Date Deposited:

13 Apr 2015 16:39

Last Modified:

29 Oct 2015 10:19

Publisher DOI:

10.1159/000357075

PubMed ID:

24434651

BORIS DOI:

10.7892/boris.66596

URI:

https://boris.unibe.ch/id/eprint/66596

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