Arterial stiffness is increased in asthmatic children.

Steinmann, Markus; Abbas, Chiara Carolina; Singer, Florian; Casaulta Aebischer, Carmen; Regamey, Nicolas; Haffner, Dieter; Fischer, Dagmar-Christiane; Simonetti, Giacomo (2015). Arterial stiffness is increased in asthmatic children. European journal of pediatrics, 174(4), pp. 519-523. Springer 10.1007/s00431-014-2423-2

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UNLABELLED Altered arterial stiffness is a recognized risk factor of poor cardiovascular health. Chronic inflammation may increase arterial stiffness. We tested whether arterial stiffness is increased children with asthma, a chronic disease characterized by fluctuating airway and systemic inflammation. Arterial stiffness, expressed as carotid-femoral pulse wave velocity (PWVcf), was measured in 37 mild-to-moderate asthmatic children: 11 girls, median (range) age 11.1 years (6-15). PWVcf in asthma was compared to PWVcf in 65 healthy controls matched for age, height, and gender previously studied in Germany and was correlated with airway inflammation and obstruction. PWVcf was higher in asthmatic children compared to controls: PWVcf median (interquartile range) was 4.7 m/s (4.5-4.9) vs. 4.3 m/s (4.1-4.7), p < 0.0001. In asthmatic children, PWVcf was inversely associated (r (2) = 0.20, p = 0.004) with forced expiratory volume in 1 s (FEV1). This association remained significant after adjusting for possible confounders including body mass index, blood pressure, steroid use, and FeNO. CONCLUSION Arterial stiffness is increased in children with mild-to-moderate asthma. The association between impaired lung function and increased arterial stiffness suggests that severity of disease translates into detrimental effects on the cardiovascular system.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Pneumologie (Pädiatrie)
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Pneumology

UniBE Contributor:

Abbas, Chiara Carolina; Singer, Florian; Casaulta Aebischer, Carmen; Regamey, Nicolas and Simonetti, Giacomo

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0340-6199

Publisher:

Springer

Language:

English

Submitter:

André Schaller

Date Deposited:

31 Mar 2015 09:07

Last Modified:

29 Feb 2016 16:36

Publisher DOI:

10.1007/s00431-014-2423-2

PubMed ID:

25248341

BORIS DOI:

10.7892/boris.66606

URI:

https://boris.unibe.ch/id/eprint/66606

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