Current concepts: host-pathogen interactions in cystic fibrosis airways disease.

Tang, Anthony C; Turvey, Stuart E; Alves, Marco; Regamey, Nicolas; Tümmler, Burkhard; Hartl, Dominik (2014). Current concepts: host-pathogen interactions in cystic fibrosis airways disease. European respiratory review, 23(133), pp. 320-332. European Respiratory Society 10.1183/09059180.00006113

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Chronic infection and inflammation are defining characteristics of cystic fibrosis (CF) airway disease. Conditions within the airways of patients living with CF are conducive to colonisation by a variety of opportunistic bacterial, viral and fungal pathogens. Improved molecular identification of microorganisms has begun to emphasise the polymicrobial nature of infections in the CF airway microenvironment. Changes to CF airway physiology through loss of cystic fibrosis transmembrane conductance regulator functionality result in a wide range of immune dysfunctions, which permit pathogen colonisation and persistence. This review will summarise the current understanding of how CF pathogens infect, interact with and evade the CF host.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Pneumologie (Pädiatrie)
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Pneumologie (Pädiatrie)

UniBE Contributor:

Alves, Marco and Regamey, Nicolas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0905-9180

Publisher:

European Respiratory Society

Language:

English

Submitter:

André Schaller

Date Deposited:

13 Apr 2015 16:10

Last Modified:

13 Apr 2015 16:10

Publisher DOI:

10.1183/09059180.00006113

PubMed ID:

25176968

BORIS DOI:

10.7892/boris.66607

URI:

https://boris.unibe.ch/id/eprint/66607

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