Sheep persistently infected with Border disease readily transmit virus to calves seronegative to BVD virus.

Braun, U; Reichle, S F; Reichert, C; Hässig, M; Stalder, H P; Bachofen, Claudia; Peterhans, Ernst (2014). Sheep persistently infected with Border disease readily transmit virus to calves seronegative to BVD virus. Veterinary microbiology, 168(1), pp. 98-104. Elsevier 10.1016/j.vetmic.2013.11.004

[img] Text
1-s2.0-S0378113513005038-main.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (981kB) | Request a copy

Bovine viral diarrhea- and Border disease viruses of sheep belong to the highly diverse genus pestivirus of the Flaviviridae. Ruminant pestiviruses may infect a wide range of domestic and wild cloven-hooved mammals (artiodactyla). Due to its economic importance, programs to eradicate bovine viral diarrhea are a high priority in the cattle industry. By contrast, Border disease is not a target of eradication, although the Border disease virus is known to be capable of also infecting cattle. In this work, we compared single dose experimental inoculation of calves with Border disease virus with co-mingling of calves with sheep persistently infected with this virus. As indicated by seroconversion, infection was achieved only in one out of seven calves with a dose of Border disease virus that was previously shown to be successful in calves inoculated with BVD virus. By contrast, all calves kept together with persistently infected sheep readily became infected with Border disease virus. The ease of viral transmission from sheep to cattle and the antigenic similarity of bovine and ovine pestiviruses may become a problem for demonstrating freedom of BVD by serology in the cattle population.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Bachofen, Claudia and Peterhans, Ernst

Subjects:

600 Technology > 630 Agriculture
500 Science > 530 Physics

ISSN:

0378-1135

Publisher:

Elsevier

Language:

English

Submitter:

Barbara Gautschi-Steffen

Date Deposited:

07 Apr 2015 17:24

Last Modified:

15 Oct 2015 10:53

Publisher DOI:

10.1016/j.vetmic.2013.11.004

PubMed ID:

24315041

Uncontrolled Keywords:

BVD eradication, Border disease virus, Bovine viral diarrhea virus (BVD virus), Cattle, Pestivirus, Sheep

BORIS DOI:

10.7892/boris.66660

URI:

https://boris.unibe.ch/id/eprint/66660

Actions (login required)

Edit item Edit item
Provide Feedback