The porcine innate immune system: an update.

Mair, K H; Sedlak, C; Käser, T; Pasternak, A; Levast, B; Gerner, W; Saalmüller, A; Summerfield, Artur; Gerdts, V; Wilson, H L; Meurens, F (2014). The porcine innate immune system: an update. Developmental and Comparative Immunology, 45(2), pp. 321-343. Elsevier 10.1016/j.dci.2014.03.022

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Over the last few years, we have seen an increasing interest and demand for pigs in biomedical research. Domestic pigs (Sus scrofa domesticus) are closely related to humans in terms of their anatomy, genetics, and physiology, and often are the model of choice for the assessment of novel vaccines and therapeutics in a preclinical stage. However, the pig as a model has much more to offer, and can serve as a model for many biomedical applications including aging research, medical imaging, and pharmaceutical studies to name a few. In this review, we will provide an overview of the innate immune system in pigs, describe its anatomical and physiological key features, and discuss the key players involved. In particular, we compare the porcine innate immune system to that of humans, and emphasize on the importance of the pig as model for human disease.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Summerfield, Artur

Subjects:

600 Technology > 630 Agriculture

ISSN:

0145-305X

Publisher:

Elsevier

Language:

English

Submitter:

Barbara Gautschi-Steffen

Date Deposited:

09 Apr 2015 12:02

Last Modified:

15 Oct 2015 10:52

Publisher DOI:

10.1016/j.dci.2014.03.022

PubMed ID:

24709051

Uncontrolled Keywords:

Animal model, Innate immune cells, Innate response, Pig

BORIS DOI:

10.7892/boris.66683

URI:

https://boris.unibe.ch/id/eprint/66683

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