Summerfield, Artur; Meurens, François; Ricklin, Meret E (2015). The immunology of the porcine skin and its value as a model for human skin. Molecular immunology, 66(1), pp. 14-21. Elsevier 10.1016/j.molimm.2014.10.023
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The porcine skin has striking similarities to the human skin in terms of general structure, thickness, hair follicle content, pigmentation, collagen and lipid composition. This has been the basis for numerous studies using the pig as a model for wound healing, transdermal delivery, dermal toxicology, radiation and UVB effects. Considering that the skin also represents an immune organ of utmost importance for health, immune cells present in the skin of the pig will be reviewed. The focus of this review is on dendritic cells, which play a central role in the skin immune system as they serve as sentinels in the skin, which offers a large surface area exposed to the environment. Based on a literature review and original data we propose a classification of porcine dendritic cell subsets in the skin corresponding to the subsets described in the human skin. The equivalent of the human CD141(+) DC subset is CD1a(-)CD4(-)CD172a(-)CADM1(high), that of the CD1c(+) subset is CD1a(+)CD4(-)CD172a(+)CADM1(+/low), and porcine plasmacytoid dendritic cells are CD1a(-)CD4(+)CD172a(+)CADM1(-). CD209 and CD14 could represent markers of inflammatory monocyte-derived cells, either dendritic cells or macrophages. Future studies for example using transriptomic analysis of sorted populations are required to confirm the identity of these cells.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) |
UniBE Contributor: |
Summerfield, Artur, Ricklin, Meret Elisabeth |
Subjects: |
600 Technology > 630 Agriculture |
ISSN: |
0161-5890 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Barbara Gautschi-Steffen |
Date Deposited: |
14 Apr 2015 16:46 |
Last Modified: |
02 Mar 2023 23:26 |
Publisher DOI: |
10.1016/j.molimm.2014.10.023 |
PubMed ID: |
25466611 |
Uncontrolled Keywords: |
Animal model, Dendritic cells, Dermis, Epidermis, Lymphocytes, Porcine skin |
BORIS DOI: |
10.7892/boris.66691 |
URI: |
https://boris.unibe.ch/id/eprint/66691 |
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