Metabolic inflexibility and insulin resistance in obese adolescents with non-alcoholic fatty liver disease.

Lee, Sojung; Rivera-Vega, Michelle; Alsayed, Hany Mohamed Abdel Aal; Boesch, Chris; Libman, Ingrid (2015). Metabolic inflexibility and insulin resistance in obese adolescents with non-alcoholic fatty liver disease. Pediatric diabetes, 16(3), pp. 211-218. Wiley 10.1111/pedi.12141

[img] Text
pedi12141.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (674kB) | Request a copy

BACKGROUND Non-alcoholic fatty liver disease (NAFLD) is a comorbidity of childhood obesity. OBJECTIVE We examined whole-body substrate metabolism and metabolic characteristics in obese adolescents with vs. without NAFLD. SUBJECTS Twelve obese (BMI ≥ 95th percentile) adolescents with and without NAFLD [intrahepatic triglyceride (IHTG) ≥5.0% vs. <5.0%] were pair-matched for race, gender, age and % body fat. METHODS Insulin sensitivity (IS) was assessed by a 3-h hyperinsulinemic-euglycemic clamp and whole-body substrate oxidation by indirect calorimetry during fasting and insulin-stimulated conditions. RESULTS Adolescents with NAFLD had increased (p < 0.05) abdominal fat, lipids, and liver enzymes compared with those without NAFLD. Fasting glucose concentration was not different between groups, but fasting insulin concentration was higher (p < 0.05) in the NAFLD group compared with those without. Fasting hepatic glucose production and hepatic IS did not differ (p > 0.1) between groups. Adolescents with NAFLD had higher (p < 0.05) fasting glucose oxidation and a tendency for lower fat oxidation. Adolescents with NAFLD had lower (p < 0.05) insulin-stimulated glucose disposal and lower peripheral IS compared with those without NAFLD. Although respiratory quotient (RQ) increased significantly from fasting to insulin-stimulated conditions in both groups (main effect, p < 0.001), the increase in RQ was lower in adolescents with NAFLD vs. those without (interaction, p = 0.037). CONCLUSION NAFLD in obese adolescents is associated with adverse cardiometabolic profile, peripheral insulin resistance and metabolic inflexibility.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology > DCR Magnetic Resonance Spectroscopy and Methodology (AMSM)

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Boesch, Christoph Hans

ISSN:

1399-5448

Publisher:

Wiley

Language:

English

Submitter:

Christoph Hans Boesch

Date Deposited:

10 Apr 2015 08:16

Last Modified:

01 Apr 2016 10:22

Publisher DOI:

10.1111/pedi.12141

PubMed ID:

24754380

Uncontrolled Keywords:

childhood obesity; insulin sensitivity; non-alcoholic fatty liver disease; visceral fat

BORIS DOI:

10.7892/boris.66692

URI:

https://boris.unibe.ch/id/eprint/66692

Actions (login required)

Edit item Edit item
Provide Feedback