Demonstration of species-specific and cross-reactive components of Taenia solium metacestode antigens.

Gottstein, Bruno; Tsang, V C; Schantz, P M (1986). Demonstration of species-specific and cross-reactive components of Taenia solium metacestode antigens. The American Journal of Tropical Medicine and Hygiene, 35(2), pp. 308-313. American Society of Tropical Medicine and Hygiene

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Analysis of human serum reactivities to antigenic components of soluble Taenia solium metacestode proteins showed the predominant presence of determinants shared by T. solium, Echinococcus multilocularis and E. granulosus. Two polypeptides were demonstrated by SDS-PAGE and Western blot or enzyme-linked immunoelectrotransfer blot (EITB) assay to bind serum and CSF antibodies only from T. solium cysticercosis patients. These species-specific antigenic polypeptides focused between pH 4.6 and 3.9 after resolution by isoelectric focusing followed by EITB. The high species-specificity demonstrated by the present techniques offers the opportunity to confirm serologically an infection by T. solium metacestode.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Gottstein, Bruno

Subjects:

600 Technology > 630 Agriculture

ISSN:

0002-9637

Publisher:

American Society of Tropical Medicine and Hygiene

Language:

English

Submitter:

Bruno Gottstein

Date Deposited:

14 Apr 2015 17:09

Last Modified:

14 Apr 2015 17:09

PubMed ID:

3082229

URI:

https://boris.unibe.ch/id/eprint/66734

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