Wattles in goats are associated with the FMN1/GREM1 region on chromosome 10.

Reber, Irene; Keller, Irene; Becker, Doreen; Flury, C; Welle, Monika Maria; Drögemüller, Cord (2015). Wattles in goats are associated with the FMN1/GREM1 region on chromosome 10. Animal genetics, 46(3), pp. 316-320. Blackwell 10.1111/age.12279

[img]
Preview
Text
Reber_et_al-2015-Animal_Genetics.pdf - Published Version
Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND).

Download (606kB) | Preview

The presence of congenital appendages (wattles) on the throat of goats is supposed to be under genetic control with a dominant mode of inheritance. Wattles contain a cartilaginous core covered with normal skin resembling early stages of extremities. To map the dominant caprine wattles (W) locus, we collected samples of 174 goats with wattles and 167 goats without wattles from nine different Swiss goat breeds. The samples were genotyped with the 53k goat SNP chip for a subsequent genome-wide association study. We obtained a single strong association signal on chromosome 10 in a region containing functional candidate genes for limb development and outgrowth. We sequenced the whole genomes of an informative family trio containing an offspring without wattles and its heterozygous parents with wattles. In the associated goat chromosome 10 region, a total of 1055 SNPs and short indels perfectly co-segregate with the W allele. None of the variants were perfectly associated with the phenotype after analyzing the genome sequences of eight additional goats. We speculate that the causative mutation is located in one of the numerous gaps in the current version of the goat reference sequence and/or represents a larger structural variant which influences the expression of the FMN1 and/or GREM1 genes. Also, we cannot rule out possible genetic or allelic heterogeneity. Our genetic findings support earlier assumptions that wattles are rudimentary developed extremities.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > DermFocus
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

UniBE Contributor:

Reber, Irene; Keller, Irene; Becker, Doreen; Welle, Monika Maria and Drögemüller, Cord

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 590 Animals (Zoology)
600 Technology > 630 Agriculture

ISSN:

0268-9146

Publisher:

Blackwell

Language:

English

Submitter:

Cord Drögemüller

Date Deposited:

21 Apr 2015 16:42

Last Modified:

01 Jul 2015 16:47

Publisher DOI:

10.1111/age.12279

PubMed ID:

25736034

Uncontrolled Keywords:

genome sequencing; genome-wide association study; limb development; livestock; skin appendages

BORIS DOI:

10.7892/boris.66881

URI:

https://boris.unibe.ch/id/eprint/66881

Actions (login required)

Edit item Edit item
Provide Feedback