The effectiveness and safety of rescue treatments in 108 patients with steroid-refractory ulcerative colitis with sequential rescue therapies in a subgroup of patients

Protic, Marijana; Seibold, Frank Werner; Schöpfer, Alain; Radojicic, Zoran; Juillerat, Pascal; Bojic, Daniela; Mwinyi, Jessica; Mottet, Christian; Jojic, Njegica; Beglinger, Christoph; Vavricka, Stephan; Rogler, Gerhard; Frei, Pascal (2014). The effectiveness and safety of rescue treatments in 108 patients with steroid-refractory ulcerative colitis with sequential rescue therapies in a subgroup of patients. Journal of Crohn's & Colitis, 8(11), pp. 1427-1437. Elsevier 10.1016/j.crohns.2014.05.004

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BACKGROUND: Among patients with steroid-refractory ulcerative colitis (UC) in whom a first rescue therapy has failed, a second line salvage treatment can be considered to avoid colectomy. AIM: To evaluate the efficacy and safety of second or third line rescue therapy over a one-year period. METHODS: Response to single or sequential rescue treatments with infliximab (5mg/kg intravenously (iv) at week 0, 2, 6 and then every 8weeks), ciclosporin (iv 2mg/kg/daily and then oral 5mg/kg/daily) or tacrolimus (0.05mg/kg divided in 2 doses) in steroid-refractory moderate to severe UC patients from 7 Swiss and 1 Serbian tertiary IBD centers was retrospectively studied. The primary endpoint was the one year colectomy rate. RESULTS: 60% of patients responded to the first rescue therapy, 10% went to colectomy and 30% non-responders were switched to a 2(nd) line rescue treatment. 66% of patients responded to the 2(nd) line treatment whereas 34% failed, of which 15% went to colectomy and 19% received a 3(rd) line rescue treatment. Among those, 50% patients went to colectomy. Overall colectomy rate of the whole cohort was 18%. Steroid-free remission rate was 39%. The adverse event rates were 33%, 37.5% and 30% for the first, second and third line treatment respectively. CONCLUSION: Our data show that medical intervention even with 2(nd) and 3(rd) rescue treatments decreased colectomy frequency within one year of follow up. A longer follow-up will be necessary to investigate whether sequential therapy will only postpone colectomy and what percentage of patients will remain in long-term remission.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology

UniBE Contributor:

Seibold, Frank Werner; Schöpfer, Alain and Juillerat, Pascal

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1873-9946

Publisher:

Elsevier

Language:

English

Submitter:

Lilian Karin Smith-Wirth

Date Deposited:

22 Apr 2015 08:55

Last Modified:

15 Sep 2017 02:45

Publisher DOI:

10.1016/j.crohns.2014.05.004

PubMed ID:

24908178

Uncontrolled Keywords:

Ciclosporin; Inflammatory bowel disease; Infliximab; Tacrolimus; Ulcerative colitis

BORIS DOI:

10.7892/boris.66970

URI:

https://boris.unibe.ch/id/eprint/66970

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