Novel Nonbiologic Therapies for Ulcerative Colitis

Juillerat, Pascal; Korzenik., JR (2014). Novel Nonbiologic Therapies for Ulcerative Colitis. In: Lichtenstein, Gary R. (ed.) Medical Therapy of Ulcerative Colitis (pp. 221-235). New York: Springer Science & Business Media 2014 10.1007/978-1-4939-1677-1_19

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An extensive array of compounds has been studied for the treatment of ulcerative colitis (UC). The most frequently used nonbiologic drugs for the oral and intravenous treatment of ulcerative colitis include 5-aminosalicylate (5-ASA) drugs (mesalamine and derivatives), sulfasalazine, and other azo-bonded molecules of 5-ASA, steroids, calcineurin inhibitors (cyclosporine, tacrolimus, and sirolimus), thiopurines (azathioprine, 6-mercaptopurine), and methotrexate, which are already presented in other sections of this book and are thus not considered in this chapter. The therapies presented in this section should be considered as potential alternatives, mostly for mild-to-moderate ulcerative colitis (UC). They are substances mostly used without FDA indications, such as heparin, nicotine, rosiglitazone, and N-acetylcysteine as well as “natural” compounds suggested to have anti-inflammatory or reparative properties, such as aloe vera, curcumin, short-chain fatty acids, and Bowman-Birk inhibitor

Item Type:

Book Section (Book Chapter)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology

UniBE Contributor:

Juillerat, Pascal

Subjects:

600 Technology > 610 Medicine & health

ISBN:

978-1-4939-1676-4

Publisher:

Springer Science & Business Media 2014

Language:

English

Submitter:

Lilian Karin Smith-Wirth

Date Deposited:

30 Mar 2015 11:19

Last Modified:

13 Oct 2017 07:48

Publisher DOI:

10.1007/978-1-4939-1677-1_19

BORIS DOI:

10.7892/boris.66971

URI:

https://boris.unibe.ch/id/eprint/66971

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