B cells as a critical node in the microbiota-host immune system network.

Slack, Emma; Balmer, Maria Luisa; Macpherson, Andrew (2014). B cells as a critical node in the microbiota-host immune system network. Immunological reviews, 260(1), pp. 50-66. Wiley-Blackwell 10.1111/imr.12179

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Mutualism with our intestinal microbiota is a prerequisite for healthy existence. This requires physical separation of the majority of the microbiota from the host (by secreted antimicrobials, mucus, and the intestinal epithelium) and active immune control of the low numbers of microbes that overcome these physical and chemical barriers, even in healthy individuals. In this review, we address how B-cell responses to members of the intestinal microbiota form a robust network with mucus, epithelial integrity, follicular helper T cells, innate immunity, and gut-associated lymphoid tissues to maintain host-microbiota mutualism.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie

UniBE Contributor:

Slack, Emma; Balmer, Maria Luisa and Macpherson, Andrew

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0105-2896

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Lilian Karin Smith-Wirth

Date Deposited:

20 Apr 2015 14:40

Last Modified:

06 Nov 2015 09:41

Publisher DOI:

10.1111/imr.12179

PubMed ID:

24942681

Uncontrolled Keywords:

B lymphocytes; IgA; gut-associated lymphoid tissue; innate immunity; intestinal barrier; microbiota

BORIS DOI:

10.7892/boris.66988

URI:

https://boris.unibe.ch/id/eprint/66988

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