Optimizing the aquatic toxicity assessment under REACH through an integrated testing strategy (ITS).

Lombardo, Anna; Roncaglioni, Alessandra; Benfenati, Emilio; Nendza, Monika; Segner, Helmut; Jeram, Sonja; Pauné, Eduard; Schüürmann, Gerrit (2014). Optimizing the aquatic toxicity assessment under REACH through an integrated testing strategy (ITS). Environmental research, 135, pp. 156-164. Elsevier 10.1016/j.envres.2014.09.002

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To satisfy REACH requirements a high number of data on chemical of interest should be supplied to the European Chemicals Agency. To organize the various kinds of information and help the registrants to choose the best strategy to obtain the needed information limiting at the minimum the use of animal testing, integrated testing strategies (ITSs) schemes can be used. The present work deals with regulatory data requirements for assessing the hazards of chemicals to the aquatic pelagic environment. We present an ITS scheme for organizing and using the complex existing data available for aquatic toxicity assessment. An ITS to optimize the choice of the correct prediction strategy for aquatic pelagic toxicity is described. All existing information (like physico-chemical information), and all the alternative methods (like in silico, in vitro or the acute-to-chronic ratio) are considered. Moreover the weight of evidence approach to combine the available data is included.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Center for Fish and Wildlife Health (FIWI)

UniBE Contributor:

Segner, Helmut

Subjects:

600 Technology > 630 Agriculture

ISSN:

0013-9351

Publisher:

Elsevier

Language:

English

Submitter:

Lucia Gugger-Raaflaub

Date Deposited:

23 Apr 2015 12:47

Last Modified:

12 Oct 2015 15:28

Publisher DOI:

10.1016/j.envres.2014.09.002

PubMed ID:

25262089

Uncontrolled Keywords:

Alternative methods, Aquatic toxicity, Hazard assessment, ITS, REACH

BORIS DOI:

10.7892/boris.66993

URI:

https://boris.unibe.ch/id/eprint/66993

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