The interplay between the gut microbiota and the immune system.

Geuking, Markus; Köller, Yasmin; Rupp, Sandra; McCoy, Kathleen (2014). The interplay between the gut microbiota and the immune system. Gut microbes, 5(3), pp. 411-418. Landes Bioscience 10.4161/gmic.29330

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The impact of the gut microbiota on immune homeostasis within the gut and, importantly, also at systemic sites has gained tremendous research interest over the last few years. The intestinal microbiota is an integral component of a fascinating ecosystem that interacts with and benefits its host on several complex levels to achieve a mutualistic relationship. Host-microbial homeostasis involves appropriate immune regulation within the gut mucosa to maintain a healthy gut while preventing uncontrolled immune responses against the beneficial commensal microbiota potentially leading to chronic inflammatory bowel diseases (IBD). Furthermore, recent studies suggest that the microbiota composition might impact on the susceptibility to immune-mediated disorders such as autoimmunity and allergy. Understanding how the microbiota modulates susceptibility to these diseases is an important step toward better prevention or treatment options for such diseases.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Geuking, Markus; Köller, Yasmin; Rupp, Sandra and McCoy, Kathleen

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1949-0976

Publisher:

Landes Bioscience

Language:

English

Submitter:

Lilian Karin Smith-Wirth

Date Deposited:

21 Apr 2015 13:40

Last Modified:

18 May 2016 14:20

Publisher DOI:

10.4161/gmic.29330

PubMed ID:

24922519

Uncontrolled Keywords:

IgA; allergies; autoimmunity; homeostasis; innate lymphoid cells; microbial conditioning; microbiota; regulatory T cells

BORIS DOI:

10.7892/boris.67006

URI:

https://boris.unibe.ch/id/eprint/67006

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