Commensal bacteria protect against food allergen sensitization.

Stefka, Andrew T; Feehley, Taylor; Tripathi, Prabhanshu; Qiu, Ju; McCoy, Kathleen; Mazmanian, Sarkis K; Tjota, Melissa Y; Seo, Goo-Young; Cao, Severine; Theriault, Betty R; Antonopoulos, Dionysios A; Zhou, Liang; Chang, Eugene B; Fu, Yang-Xin; Nagler, Cathryn R (2014). Commensal bacteria protect against food allergen sensitization. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 111(36), pp. 13145-13150. National Academy of Sciences NAS 10.1073/pnas.1412008111

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Environmentally induced alterations in the commensal microbiota have been implicated in the increasing prevalence of food allergy. We show here that sensitization to a food allergen is increased in mice that have been treated with antibiotics or are devoid of a commensal microbiota. By selectively colonizing gnotobiotic mice, we demonstrate that the allergy-protective capacity is conferred by a Clostridia-containing microbiota. Microarray analysis of intestinal epithelial cells from gnotobiotic mice revealed a previously unidentified mechanism by which Clostridia regulate innate lymphoid cell function and intestinal epithelial permeability to protect against allergen sensitization. Our findings will inform the development of novel approaches to prevent or treat food allergy based on modulating the composition of the intestinal microbiota.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie

UniBE Contributor:

McCoy, Kathleen

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0027-8424

Publisher:

National Academy of Sciences NAS

Language:

English

Submitter:

Lilian Karin Smith-Wirth

Date Deposited:

20 Apr 2015 11:07

Last Modified:

30 Sep 2016 15:10

Publisher DOI:

10.1073/pnas.1412008111

PubMed ID:

25157157

Uncontrolled Keywords:

IL-22; barrier; microbiome

BORIS DOI:

10.7892/boris.67007

URI:

https://boris.unibe.ch/id/eprint/67007

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