On the comparison of a novel serious game and electroencephalography biomarkers for early dementia screening

Tarnanas, Ioannis; Laskaris, Nikos; Tsolaki, Magda; Müri, René Martin; Nef, Tobias; Mosimann, Urs P. (2015). On the comparison of a novel serious game and electroencephalography biomarkers for early dementia screening. In: Vlamos, Panayiotis; Alexiou, Athanasios (eds.) GeNeDis 2014 - Geriatrics. Advances in Experimental Medicine and Biology: Vol. 821 (pp. 63-77). Cham: Springer 10.1007/978-3-319-08939-3_11

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Patients with amnestic mild cognitive impairment are at high risk for developing Alzheimer's disease. Besides episodic memory dysfunction they show deficits in accessing contextual knowledge that further specifies a general spatial navigation task or an executive function (EF) virtual action planning. Virtual reality (VR) environments have already been successfully used in cognitive rehabilitation and show increased potential for use in neuropsychological evaluation allowing for greater ecological validity while being more engaging and user friendly. In our study we employed the in-house platform of virtual action planning museum (VAP-M) and a sample of 25 MCI and 25 controls, in order to investigate deficits in spatial navigation, prospective memory, and executive function. In addition, we used the morphology of late components in event-related potential (ERP) responses, as a marker for cognitive dysfunction. The related measurements were fed to a common classification scheme facilitating the direct comparison of both approaches. Our results indicate that both the VAP-M and ERP averages were able to differentiate between healthy elders and patients with amnestic mild cognitive impairment and agree with the findings of the virtual action planning supermarket (VAP-S). The sensitivity (specificity) was 100% (98%) for the VAP-M data and 87% (90%) for the ERP responses. Considering that ERPs have proven to advance the early detection and diagnosis of "presymptomatic AD," the suggested VAP-M platform appears as an appealing alternative.

Item Type:

Book Section (Book Chapter)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Pavillon 52 > Forschungsgruppe Perzeption und Okulomotorik
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Geriatric Psychiatry and Psychotherapy
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Gerontechnology and Rehabilitation
04 Faculty of Medicine > University Psychiatric Services

UniBE Contributor:

Tarnanas, Ioannis; Müri, René Martin; Nef, Tobias and Mosimann, Urs Peter

Subjects:

100 Philosophy > 150 Psychology
600 Technology > 610 Medicine & health

ISSN:

0065-2598

ISBN:

978-3-319-08938-6

Series:

Advances in Experimental Medicine and Biology

Publisher:

Springer

Language:

English

Submitter:

Vanessa Vallejo

Date Deposited:

27 Apr 2015 10:42

Last Modified:

06 Apr 2016 00:15

Publisher DOI:

10.1007/978-3-319-08939-3_11

PubMed ID:

25416111

BORIS DOI:

10.7892/boris.67072

URI:

https://boris.unibe.ch/id/eprint/67072

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