Immunophenotyping of acute leukemia and lymphoproliferative disorders: a consensus proposal of the European LeukemiaNet Work Package 10

Béné, M C; Nebe, T; Bettelheim, P; Buldini, B; Bumbea, H; Kern, W; Lacombe, F; Lemez, P; Marinov, I; Matutes, E; Maynadié, M; Oelschlagel, U; Orfao, A; Schabath, R; Solenthaler, M; Tschurtschenthaler, G; Vladareanu, A M; Zini, G; Faure, G C and Porwit, A (2011). Immunophenotyping of acute leukemia and lymphoproliferative disorders: a consensus proposal of the European LeukemiaNet Work Package 10. Leukemia, 25(4), pp. 567-74. Basingstoke: Nature Publishing Group 10.1038/leu.2010.312

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The European LeukemiaNet (ELN), workpackage 10 (WP10) was designed to deal with diagnosis matters using morphology and immunophenotyping. This group aimed at establishing a consensus on the required reagents for proper immunophenotyping of acute leukemia and lymphoproliferative disorders. Animated discussions within WP10, together with the application of the Delphi method of proposals circulation, quickly led to post-consensual immunophenotyping panels for disorders on the ELN website. In this report, we established a comprehensive description of these panels, both mandatory and complementary, for both types of clinical conditions. The reason for using each marker, sustained by relevant literature information, is provided in detail. With the constant development of immunophenotyping techniques in flow cytometry and related software, this work aims at providing useful guidelines to perform the most pertinent exploration at diagnosis and for follow-up, with the best cost benefit in diseases, the treatment of which has a strong impact on health systems.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory

UniBE Contributor:

Solenthaler, Max

ISSN:

0887-6924

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:08

Last Modified:

17 Mar 2015 19:09

Publisher DOI:

10.1038/leu.2010.312

PubMed ID:

21252983

Web of Science ID:

000289475300002

URI:

https://boris.unibe.ch/id/eprint/673 (FactScience: 200344)

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