BDNF Val66Met polymorphism influence on striatal blood-level-dependent response to monetary feedback depends on valence and agency

Chumbley, J.; Späti, J.; Dörig, N.; Brakowski, J.; Grosse Holtforth, Martin; Seifritz, E.; Spinelli, S. (2014). BDNF Val66Met polymorphism influence on striatal blood-level-dependent response to monetary feedback depends on valence and agency. Neuroscience, 280, pp. 130-141. Elsevier 10.1016/j.neuroscience.2014.09.014

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Animal work implicates the brain-derived neurotrophic factor (BDNF) in function of the ventral striatum (VS), a region known for its role in processing valenced feedback. Recent evidence in humans shows that BDNF Val66Met polymorphism modulates VS activity in anticipation of monetary feedback. However, it remains unclear whether the polymorphism impacts the processing of self-attributed feedback differently from feedback attributed to an external agent. In this study, we emphasize the importance of the feedback attribution because agency is central to computational accounts of the striatum and cognitive accounts of valence processing. We used functional magnetic resonance imaging and a task, in which financial gains/losses are either attributable to performance (self-attributed, SA) or chance (externally-attributed, EA) to ask whether BDNF Val66Met polymorphism predicts VS activity. We found that BDNF Val66Met polymorphism influenced how feedback valence and agency information were combined in the VS and in the right inferior frontal junction (IFJ). Specifically, Met carriers' VS response to valenced feedback depended on agency information, while Val/Val carriers' VS response did not. This context-specific modulation of valence effectively amplified VS responses to SA losses in Met carriers. The IFJ response to SA losses also differentiated Val/Val from Met carriers. These results may point to a reduced allocation of attention and altered motivational salience to SA losses in Val/Val compared to Met carriers. Implications for major depressive disorder are discussed.

Item Type:

Journal Article (Original Article)

Division/Institute:

07 Faculty of Human Sciences > Institute of Psychology > Clinical Psychology and Psychotherapy
07 Faculty of Human Sciences > Institute of Psychology

UniBE Contributor:

grosse Holtforth, Martin

Subjects:

100 Philosophy > 150 Psychology
600 Technology > 610 Medicine & health

ISSN:

0306-4522

Publisher:

Elsevier

Language:

English

Submitter:

Adriana Biaggi

Date Deposited:

21 Apr 2015 14:47

Last Modified:

21 Apr 2015 14:47

Publisher DOI:

10.1016/j.neuroscience.2014.09.014

Uncontrolled Keywords:

Brain-derived neurotrophic factor gene, Val66Met, feedback processing, inferior frontal junction, ventral striatum, functional magnetic resonance imaging

BORIS DOI:

10.7892/boris.67374

URI:

https://boris.unibe.ch/id/eprint/67374

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