Refinement of experimental design and conduct in laboratory animal research.

Bailoo, Jeremy Davidson; Reichlin, Thomas Stephan Albin; Würbel, Hanno (2014). Refinement of experimental design and conduct in laboratory animal research. Institute for Laboratory Animal Research, 55(3), pp. 383-391. Oxford University Press 10.1093/ilar/ilu037

Text ilu037.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (212kB)

The scientific literature of laboratory animal research is replete with papers reporting poor reproducibility of results as well as failure to translate results to clinical trials in humans. This may stem in part from poor experimental design and conduct of animal experiments. Despite widespread recognition of these problems and implementation of guidelines to attenuate them, a review of the literature suggests that experimental design and conduct of laboratory animal research are still in need of refinement. This paper will review and discuss possible sources of biases, highlight advantages and limitations of strategies proposed to alleviate them, and provide a conceptual framework for improving the reproducibility of laboratory animal research.

Interest & Impact

Downloads

1 since deposited on 29 Apr 2015
0 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item