Refinement of experimental design and conduct in laboratory animal research.

Bailoo, Jeremy Davidson; Reichlin, Thomas Stephan Albin; Würbel, Hanno (2014). Refinement of experimental design and conduct in laboratory animal research. Institute for Laboratory Animal Research, 55(3), pp. 383-391. Oxford University Press 10.1093/ilar/ilu037

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The scientific literature of laboratory animal research is replete with papers reporting poor reproducibility of results as well as failure to translate results to clinical trials in humans. This may stem in part from poor experimental design and conduct of animal experiments. Despite widespread recognition of these problems and implementation of guidelines to attenuate them, a review of the literature suggests that experimental design and conduct of laboratory animal research are still in need of refinement. This paper will review and discuss possible sources of biases, highlight advantages and limitations of strategies proposed to alleviate them, and provide a conceptual framework for improving the reproducibility of laboratory animal research.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Veterinary Public Health Institute > Animal Welfare Division
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

UniBE Contributor:

Bailoo, Jeremy Davidson; Reichlin, Thomas Stephan Albin and Würbel, Hanno

ISSN:

1084-2020

Publisher:

Oxford University Press

Funders:

[18] European Research Council
[UNSPECIFIED] FP7 Coordination and Support Action
[UNSPECIFIED] Swiss Federal Food Safety and Veterinary Office

Projects:

[UNSPECIFIED] ERC Advance Grant REFINE
[UNSPECIFIED] Multi-PART

Language:

English

Submitter:

Jeremy Davidson Bailoo

Date Deposited:

29 Apr 2015 11:18

Last Modified:

29 Apr 2015 11:18

Publisher DOI:

10.1093/ilar/ilu037

PubMed ID:

25541540

URI:

https://boris.unibe.ch/id/eprint/67465

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