An fMRI-Study on context-specificity of inhibitory functions in alcohol-dependency: Preliminary results

Heri, Kathryn; Fey, Werner Martin; Federspiel, Andrea; Moggi, Franz; Stein, Maria; Heri, Kathryn (1 February 2014). An fMRI-Study on context-specificity of inhibitory functions in alcohol-dependency: Preliminary results (Unpublished). In: SAN2014 Meeting of the Society of Applied Neurosciences. Utrecht, Holland. 30.01.-02.02.2014.

Introduction: Alcohol-dependency is a common disease with many negative consequences in the daily life. A typical symptom of alcoholic-patients is the persistent and uncontrollable desire to consume alcohol. Inspite of different treatments, alcohol-dependency has a relapse rate of about 85%. This high rate is facilitated by a dysfunction of cognitive control-processes. In order to understand this disease sustaining factor, the present study investigated the neurophysiological correlates of inhibition of alcoholic-patients in a neutral as well as an alcohol-related context. Methods: A total of 18 participants, (9 alcohol-dependent-patients (age range: 27-62 years), 9 healthy controls (age range: 29-60 years)) have been measured with functional magnetic resonance imaging while they participated in an alcohol-specific Go/NoGo-Task. Neurophysiological correlates of inhibition in an alcohol-related as well as a neutral context were compared in both groups. Results: When comparing correct stop-trials in alcohol-related to neutral context, only alcohol-dependent patients showed significant hyperactivation in frontal regions (superior and medial gyrus frontalis, anterior gyrus cinguli, gyrus paracentralis and the gyrus praecentralis). No significant differences were found in any of the behavioral analyses. Discussion: These preliminary results thus indicate that successful inhibition in a drug-related context demands additional resources in patients. Especially the hyperactivation of the anterior gyrus cinguli might be important because of its involvement in decision-processes. In the absent of deficits in behavioral data, this suggests that alcohol-dependent patients need more neuronal activity to achieve the same performance-level like healthy controls.

Item Type:

Conference or Workshop Item (Poster)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology (discontinued)
07 Faculty of Human Sciences > Institute of Psychology > Developmental Psychology
07 Faculty of Human Sciences > Institute of Psychology > Clinical Psychology and Psychotherapy
07 Faculty of Human Sciences > Institute of Psychology
04 Faculty of Medicine > University Psychiatric Services

UniBE Contributor:

Heri, Kathryn; Fey, Werner Martin; Federspiel, Andrea; Moggi, Franz; Stein, Maria and Heri, Kathryn

Subjects:

100 Philosophy > 150 Psychology
600 Technology > 610 Medicine & health

Language:

English

Submitter:

Adriana Biaggi

Date Deposited:

21 Apr 2015 16:01

Last Modified:

12 Dec 2017 08:56

URI:

https://boris.unibe.ch/id/eprint/67551

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