Plasma T-cadherin negatively associates with coronary lesion severity and acute coronary syndrome.

Pfaff, Dennis; Schoenenberger, Andreas; Dasen, Boris; Erne, Paul; Resink, Therese J; Philippova, Maria (2015). Plasma T-cadherin negatively associates with coronary lesion severity and acute coronary syndrome. European Heart Journal: Acute Cardiovascular Care, 4(5), pp. 410-418. Sage 10.1177/2048872614557229

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AIMS This study evaluated associations between plasma T-cadherin levels and severity of atherosclerotic disease. METHODS AND RESULTS Three hundred and ninety patients undergoing coronary angiography were divided into three groups based on clinical and angiographic presentation: a group (n=40) with normal coronary arteries, a group (n=250) with chronic coronary artery disease and a group (n=100) with acute coronary syndrome. Plasma T-cadherin levels were measured by double sandwich ELISA. Intravascular ultrasound data of the left-anterior descending artery were acquired in a subgroup of 284 patients. T-cadherin levels were lower in patients with acute coronary syndrome than in normal patients (p=0.007) and patients with chronic coronary artery disease (p=0.002). Levels were lower in males (p=0.002), in patients with hypertension (p=0.002) and inpatients with diabetes (p=0.008), and negatively correlated with systolic blood pressure (p=0.014), body mass index (p=0.001) and total number of risk factors (p=0.001). T-cadherin negatively associated with angiographic severity of disease (p=0.001) and with quantitative intravascular ultrasound measures of lesion severity (p<0.001 for plaque, necrotic core and dense calcium volumes). Significant associations between T-cadherin and intravascular ultrasound measurements persisted even if the regression model was adjusted for the presence of acute coronary syndrome. Multivariate analysis identified a strong (p=0.002) negative association of T-cadherin with acute coronary syndrome, and lower T-cadherin levels significantly (p=0.002) associated with a higher risk of acute coronary syndrome independently of age, gender and cardiovascular risk factors. CONCLUSIONS A reduction in plasma T-cadherin levels is associated with increasing severity of coronary artery disease and a higher risk for acute coronary syndrome.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Geriatric Clinic
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine

UniBE Contributor:

Schoenenberger, Andreas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2048-8734

Publisher:

Sage

Language:

English

Submitter:

Rebecca Rufer

Date Deposited:

29 Apr 2015 12:34

Last Modified:

25 Apr 2017 11:35

Publisher DOI:

10.1177/2048872614557229

PubMed ID:

25344491

Uncontrolled Keywords:

Circulating T-cadherin, ELISA, acute coronary syndrome, coronary artery disease severity, intravascular ultrasound

BORIS DOI:

10.7892/boris.67575

URI:

https://boris.unibe.ch/id/eprint/67575

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