Laparoscopic management of bowel endometriosis: resection margins as a predictor of recurrence.

Nirgianakis, Konstantinos; Mc Kinnon, Brett; Imboden, Sara; Knabben, Laura Michelle Tatjana; Gloor, Beat; Mueller, Michael (2014). Laparoscopic management of bowel endometriosis: resection margins as a predictor of recurrence. Acta obstetricia et gynecologica Scandinavica, 93(12), pp. 1262-1267. Wiley-Blackwell 10.1111/aogs.12490

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OBJECTIVE To evaluate possible predictive factors for recurrence after laparoscopic segmental bowel resection for bowel endometriosis. DESIGN Cohort study. SETTING Academic tertiary referral center. METHODS 95 symptomatic women with bowel endometriosis who underwent laparoscopic segmental bowel resection at the Endometriosis clinic, University of Berne, between 2002 and 2012 were enrolled. Since 14 women were lost to follow-up, 81 formed the final cohort. Clinical and histological characteristics were examined as possible predictive factors for disease recurrence. MAIN OUTCOME MEASURES Recurrence, defined as a subsequent operation due to recurrent endometriosis-associated pain with a histologically confirmed endometriotic lesion. RESULTS Recurrence was observed in 13 (16%) patients. Variables that were significantly associated to recurrence by the Cox regression analysis were positive bowel resection margins (hazard ratio 6.5, 95% confidence interval 1.8-23.5, p = 0.005), age <31 years (hazard ratio 5.6, 95% confidence interval 1.7-18.6, p = 0.005) and body mass index ≥23 kg/m(2) (hazard ratio 11.0, 95% confidence interval 2.7-44.6, p = 0.001). CONCLUSIONS Positive bowel resection margins as well as age <31 years and body mass index ≥23 kg/m(2) appear to be independent predictors of disease recurrence.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Endometriose und gynäkologische Onkologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Endometriose und gynäkologische Onkologie

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery

UniBE Contributor:

Nirgianakis, Konstantinos; Mc Kinnon, Brett; Imboden, Sara; Knabben, Laura Michelle Tatjana; Gloor, Beat and Mueller, Michael

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0001-6349

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Lilian Karin Smith-Wirth

Date Deposited:

17 Apr 2015 15:12

Last Modified:

06 Nov 2015 09:38

Publisher DOI:

10.1111/aogs.12490

PubMed ID:

25175300

Uncontrolled Keywords:

Bowel endometriosis; recurrence; resection margins; segmental resection

BORIS DOI:

10.7892/boris.67700

URI:

https://boris.unibe.ch/id/eprint/67700

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