Effects of dark chocolate consumption on the prothrombotic response to acute psychosocial stress in healthy men

von Känel, R.; Meister, R. E.; Stutz, M.; Kummer, P.; Arpagaus, A.; Huber, S.; Ehlert, U.; Wirtz, P. H. (2014). Effects of dark chocolate consumption on the prothrombotic response to acute psychosocial stress in healthy men. Thrombosis and haemostasis, 112(6), pp. 1151-1158. Schattauer 10.1160/TH14-05-0450

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Flavanoid-rich dark chocolate consumption benefits cardiovascular health, but underlying mechanisms are elusive. We investigated the acute effect of dark chocolate on the reactivity of prothrombotic measures to psychosocial stress. Healthy men aged 20-50 years (mean ± SD: 35.7 ± 8.8) were assigned to a single serving of either 50 g of flavonoid-rich dark chocolate (n=31) or 50 g of optically identical flavonoid-free placebo chocolate (n=34). Two hours after chocolate consumption, both groups underwent an acute standardised psychosocial stress task combining public speaking and mental arithmetic. We determined plasma levels of four stress-responsive prothrombotic measures (i. e., fibrinogen, clotting factor VIII activity, von Willebrand Factor antigen, fibrin D-dimer) prior to chocolate consumption, immediately before and after stress, and at 10 minutes and 20 minutes after stress cessation. We also measured the flavonoid epicatechin, and the catecholamines epinephrine and norepinephrine in plasma. The dark chocolate group showed a significantly attenuated stress reactivity of the hypercoagulability marker D-dimer (F=3.87, p=0.017) relative to the placebo chocolate group. Moreover, the blunted D-dimer stress reactivity related to higher plasma levels of the flavonoid epicatechin assessed before stress (F=3.32, p = 0.031) but not to stress-induced changes in catecholamines (p's=0.35). There were no significant group differences in the other coagulation measures (p's≥0.87). Adjustments for covariates did not alter these findings. In conclusion, our findings indicate that a single consumption of flavonoid-rich dark chocolate blunted the acute prothrombotic response to psychosocial stress, thereby perhaps mitigating the risk of acute coronary syndromes triggered by emotional stress.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Psychosomatik
07 Faculty of Human Sciences > Institute of Psychology > Clinical Psychology and Psychotherapy
07 Faculty of Human Sciences > Institute of Psychology

UniBE Contributor:

von Känel, Roland; Meister, Rebecca Elisabeth; Stutz, Monika and Wirtz, Petra Hedwig

Subjects:

600 Technology > 610 Medicine & health
100 Philosophy > 150 Psychology

ISSN:

0340-6245

Publisher:

Schattauer

Language:

English

Submitter:

Adriana Biaggi

Date Deposited:

22 Apr 2015 15:07

Last Modified:

05 Nov 2019 07:14

Publisher DOI:

10.1160/TH14-05-0450

PubMed ID:

25208561

Uncontrolled Keywords:

Blood coagulation, cardiovascular disease, catecholamines, epicatechin, psychological stress

BORIS DOI:

10.7892/boris.67781

URI:

https://boris.unibe.ch/id/eprint/67781

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