The role of rituximab in the treatment of ANCA-associated vasculitides (AAV).

Daikeler, Thomas; Kistler, Andreas D; Martin, Pierre-Yves; Vogt, Bruno; Huynh-Do, Uyen (2015). The role of rituximab in the treatment of ANCA-associated vasculitides (AAV). Swiss medical weekly, 145(w14103), w14103. EMH Schweizerischer Ärzteverlag 10.4414/smw.2015.14103

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The antineutrophil cytoplasmic antibody (ANCA) associated vasculitides (AAV) are a group of primary vasculitides that affect predominantly small- to medium-sized blood vessels. AAV include granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA). Disease severity is dictated by the location and extent of the blood vessels affected. If left untreated, systemic forms of AAV are often fatal. The advent of immunosuppressive therapy (cyclophosphamide plus glucocorticoids) has revolutionised the prognosis for patients with AAV, transforming the course of the disease from fatal to one that can be managed, though not without significant treatment-related toxicity. Recently, the monoclonal antibody rituximab was approved for the treatment of GPA and MPA, providing the first major alternative to cyclophosphamide for induction therapy of AAV. This review explores the emerging role of rituximab in the management of this complex disorder.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension

UniBE Contributor:

Huynh-Do, Uyen

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1424-7860

Publisher:

EMH Schweizerischer Ärzteverlag

Language:

English

Submitter:

Uyen Huynh-Do

Date Deposited:

08 Jun 2017 16:37

Last Modified:

11 Jun 2017 01:57

Publisher DOI:

10.4414/smw.2015.14103

PubMed ID:

25658140

BORIS DOI:

10.7892/boris.67794

URI:

https://boris.unibe.ch/id/eprint/67794

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