Anticipatory cognitive stress appraisal modulates suppression of wound-induced macrophage activation by acute psychosocial stress

Kuebler, Ulrike; Wirtz, Petra H.; Sakai, Miho; Stemmer, Andreas; Meister, Rebecca E.; Ehlert, Ulrike (2015). Anticipatory cognitive stress appraisal modulates suppression of wound-induced macrophage activation by acute psychosocial stress. Psychophysiology, 52(4), pp. 499-508. Wiley-Blackwell 10.1111/psyp.12368

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Anticipatory cognitive stress appraisal (ACSA) can affect the stress-induced release of stress hormones, which, in turn, can modulate microbicidal potential of macrophages. This study examines whether ACSA modulates wound-induced activation of macrophage microbicidal potential in 22 acutely stressed compared to 17 nonstressed healthy men. After catheter-induced wound infliction and completing the ACSA questionnaire, the stress group underwent an acute mental stress task, while the nonstressed group did not. Macrophage microbicidal potential and stress hormones were repeatedly measured. In acutely stressed men, but not in nonstressed men, higher scores in ACSA related to lower macrophage microbicidal potential. This association was statistically mediated by the norepinephrine (NE) stress response. Our data suggest that ACSA modulates stress-induced suppression of wound-induced macrophage activation and that the NE stress response underlies this effect.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
07 Faculty of Human Sciences > Institute of Psychology > Clinical Psychology and Psychotherapy
07 Faculty of Human Sciences > Institute of Psychology

UniBE Contributor:

Wirtz, Petra Hedwig and Meister, Rebecca Elisabeth

Subjects:

600 Technology > 610 Medicine & health
100 Philosophy > 150 Psychology

ISSN:

0048-5772

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Adriana Biaggi

Date Deposited:

22 Apr 2015 15:02

Last Modified:

20 Oct 2015 09:55

Publisher DOI:

10.1111/psyp.12368

PubMed ID:

25336186

Uncontrolled Keywords:

Cognitive stress appraisal, Acute psychological stress, Macrophages, Microbicidal potential, Wound healing, Norepinephrine

BORIS DOI:

10.7892/boris.67924

URI:

https://boris.unibe.ch/id/eprint/67924

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