Long-term outcome after arterial ischemic stroke in children and young adults.

Goeggel, Barbara; Cavelti, Ariane; Arnold, Marcel; Bigi, Sandra; Regényi, Mária; Mattle, Heinrich P.; Gralla, Jan; Fluss, Joel; Weber, Peter; Hackenberg, Annette; Steinlin, Maja; Fischer, Urs (2015). Long-term outcome after arterial ischemic stroke in children and young adults. Neurology, 84(19), pp. 1941-1947. Lippincott Williams & Wilkins 10.1212/WNL.0000000000001555

[img] Text
Children_YoungAdults_Neurology.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (358kB) | Request a copy


To compare long-term outcome of children and young adults with arterial ischemic stroke (AIS) from 2 large registries.


Prospective cohort study comparing functional and psychosocial long-term outcome (≥2 years after AIS) in patients who had AIS during childhood (1 month-16 years) or young adulthood (16.1-45 years) between January 2000 and December 2008, who consented to follow-up. Data of children were collected prospectively in the Swiss Neuropediatric Stroke Registry, young adults in the Bernese stroke database.


Follow-up information was available in 95/116 children and 154/187 young adults. Median follow-up of survivors was 6.9 years (interquartile range 4.7-9.4) and did not differ between the groups (p = 0.122). Long-term functional outcome was similar (p = 0.896): 53 (56%) children and 84 (55%) young adults had a favorable outcome (modified Rankin Scale 0-1). Mortality in children was 14% (13/95) and in young adults 7% (11/154) (p = 0.121) and recurrence rate did not differ (p = 0.759). Overall psychosocial impairment and quality of life did not differ, except for more behavioral problems among children (13% vs 5%, p = 0.040) and more frequent reports of an impact of AIS on everyday life among adults (27% vs 64%, p < 0.001). In a multivariate regression analysis, low Pediatric NIH Stroke Scale/NIH Stroke Scale score was the most important predictor of favorable outcome (p < 0.001).


There were no major differences in long-term outcome after AIS in children and young adults for mortality, disability, quality of life, psychological, or social variables.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Goeggel Simonetti, Barbara, Cavelti, Ariane, Arnold, Marcel, Bigi, Sandra, Regényi, Mária, Mattle, Heinrich, Gralla, Jan, Steinlin, Maja, Fischer, Urs Martin


600 Technology > 610 Medicine & health




Lippincott Williams & Wilkins




Anette van Dorland

Date Deposited:

05 May 2015 09:20

Last Modified:

02 Mar 2023 23:26

Publisher DOI:


PubMed ID:






Actions (login required)

Edit item Edit item
Provide Feedback