Depressive Symptoms at Discharge from Rehabilitation Predict Future Cardiovascular-Related Hospitalizations

Meyer, F. A.; Hugentobler, E.; Stauber, S.; Wilhelm, M.; Znoj, H.; von Känel, R. (2015). Depressive Symptoms at Discharge from Rehabilitation Predict Future Cardiovascular-Related Hospitalizations. Cardiology, 131(2), pp. 80-85. Karger 10.1159/000375231

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Objectives: Depression is associated with poor prognosis in patients with cardiovascular disease (CVD). We hypothesized that depressive symptoms at discharge from a cardiac rehabilitation program are associated with an increased risk of future CVD-related hospitalizations. Methods: We examined 486 CVD patients (mean age = 59.8 ± 11.2) who enrolled in a comprehensive 3-month rehabilitation program and completed the depression subscale of the Hospital Anxiety and Depression Scale (HADS-D). At follow-up we evaluated the predictive value of depressive symptoms for CVD-related hospitalizations, controlling for sociodemographic factors, cardiovascular risk factors, and disease severity. Results: During a mean follow-up of 41.5 ± 15.6 months, 63 patients experienced a CVD-related hospitalization. The percentage of depressive patients (HADS-D ≥ 8) decreased from 16.9% at rehabilitation entry to 10.7% at discharge. Depressive symptoms at discharge from rehabilitation were a significant predictor of outcome (HR 1.32, 95% CI 1.09–1.60; p =0.004). Patients with clinically relevant depressive symptoms at discharge had a 2.5-fold increased relative risk of poor cardiac prognosis compared to patients without clinically relevant depressive symptoms independently of other prognostic variables. Conclusion: In patients with CVD, depressive symptoms at discharge from rehabilitation indicated a poor cardiac prognosis.

Item Type:

Journal Article (Original Article)


07 Faculty of Human Sciences > Institute of Psychology > Clinical Psychology and Psychotherapy
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiovascular Surgery
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Psychosomatik

UniBE Contributor:

Meyer, Fiorenza, Wilhelm, Matthias, Znoj, Hans Jörg, von Känel, Roland


100 Philosophy > 150 Psychology
600 Technology > 610 Medicine & health








Adriana Biaggi

Date Deposited:

22 Apr 2015 15:17

Last Modified:

05 Dec 2022 14:46

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Cardiac rehabilitation, Depression, Mortality, Prospective longitudinal study




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