GoCARB in the Context of an Artificial Pancreas

Agianniotis, Aristotelis; Anthimopoulos, Marios; Daskalaki, Eleni; Drapela, Aurélie; Stettler, Christoph; Diem, Peter; Mougiakakou, Stavroula (2015). GoCARB in the Context of an Artificial Pancreas. Journal of diabetes science and technology, 9(3), pp. 549-555. Diabetes Technology Society 10.1177/1932296815583333

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Background: In an artificial pancreas (AP), the meals are either manually announced or detected and their size estimated from the blood glucose level. Both methods have limitations, which result in suboptimal postprandial glucose control. The GoCARB system is designed to provide the carbohydrate content of meals and is presented within the AP framework. Method: The combined use of GoCARB with a control algorithm is assessed in a series of 12 computer simulations. The simulations are defined according to the type of the control (open or closed loop), the use or not-use of GoCARB and the diabetics’ skills in carbohydrate estimation. Results: For bad estimators without GoCARB, the percentage of the time spent in target range (70-180 mg/dl) during the postprandial period is 22.5% and 66.2% for open and closed loop, respectively. When the GoCARB is used, the corresponding percentages are 99.7% and 99.8%. In case of open loop, the time spent in severe hypoglycemic events (<50 mg/dl) is 33.6% without the GoCARB and is reduced to 0.0% when the GoCARB is used. In case of closed loop, the corresponding percentage is 1.4% without the GoCARB and is reduced to 0.0% with the GoCARB. Conclusion: The use of GoCARB improves the control of postprandial response and glucose profiles especially in the case of open loop. However, the most efficient regulation is achieved by the combined use of the control algorithm and the GoCARB.

Item Type:

Journal Article (Original Article)

Division/Institute:

10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Diabetes Technology
04 Faculty of Medicine > Other Institutions > Office of the Dean, Faculty of Medicine > Office of the Dean, Medicine
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > University Emergency Center

UniBE Contributor:

Agianniotis, Aristotelis; Anthimopoulos, Marios; Daskalaki, Eleni; Drapela, Aurélie; Stettler, Christoph; Diem, Peter and Mougiakakou, Stavroula

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1932-2968

Publisher:

Diabetes Technology Society

Language:

English

Submitter:

Stavroula Mougiakakou

Date Deposited:

07 May 2015 14:12

Last Modified:

07 May 2015 14:12

Publisher DOI:

10.1177/1932296815583333

PubMed ID:

25904142

URI:

https://boris.unibe.ch/id/eprint/68158

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