Multi-Model Data Fusion to Improve an Early Warning System for Hypo-/Hyperglycemic Events

Botwey, Ransford Henry; Daskalaki, Eleni; Diem, Peter; Mougiakakou, Stavroula (August 2014). Multi-Model Data Fusion to Improve an Early Warning System for Hypo-/Hyperglycemic Events. IEEE Engineering in Medicine and Biology Society conference proceedings, 2014, pp. 4843-4846. IEEE Service Center 10.1109/EMBC.2014.6944708

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Correct predictions of future blood glucose levels in individuals with Type 1 Diabetes (T1D) can be used to provide early warning of upcoming hypo-/hyperglycemic events and thus to improve the patient's safety. To increase prediction accuracy and efficiency, various approaches have been proposed which combine multiple predictors to produce superior results compared to single predictors. Three methods for model fusion are presented and comparatively assessed. Data from 23 T1D subjects under sensor-augmented pump (SAP) therapy were used in two adaptive data-driven models (an autoregressive model with output correction - cARX, and a recurrent neural network - RNN). Data fusion techniques based on i) Dempster-Shafer Evidential Theory (DST), ii) Genetic Algorithms (GA), and iii) Genetic Programming (GP) were used to merge the complimentary performances of the prediction models. The fused output is used in a warning algorithm to issue alarms of upcoming hypo-/hyperglycemic events. The fusion schemes showed improved performance with lower root mean square errors, lower time lags, and higher correlation. In the warning algorithm, median daily false alarms (DFA) of 0.25%, and 100% correct alarms (CA) were obtained for both event types. The detection times (DT) before occurrence of events were 13.0 and 12.1 min respectively for hypo-/hyperglycemic events. Compared to the cARX and RNN models, and a linear fusion of the two, the proposed fusion schemes represents a significant improvement.

Item Type:

Conference or Workshop Item (Paper)

Division/Institute:

10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Diabetes Technology
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition

UniBE Contributor:

Botwey, Ransford Henry; Daskalaki, Eleni; Diem, Peter and Mougiakakou, Stavroula

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1557-170X

Publisher:

IEEE Service Center

Language:

English

Submitter:

Stavroula Mougiakakou

Date Deposited:

13 May 2015 12:09

Last Modified:

26 Jun 2016 02:02

Publisher DOI:

10.1109/EMBC.2014.6944708

PubMed ID:

25571076

BORIS DOI:

10.7892/boris.68162

URI:

https://boris.unibe.ch/id/eprint/68162

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