Antagonistic TSC22D1 variants control BRAF(E600)-induced senescence

Hömig-Hölzel, Cornelia; van Doorn, Remco; Vogel, Celia; Germann, Markus; Cecchini, Marco G; Verdegaal, Els; Peeper, Daniel S (2011). Antagonistic TSC22D1 variants control BRAF(E600)-induced senescence. EMBO journal, 30(9), pp. 1753-65. London: Nature Publishing Group 10.1038/emboj.2011.95

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Oncogene-induced cellular senescence (OIS) is an increasingly recognized tumour suppressor mechanism that confines the outgrowth of neoplastic cells in vivo. It relies on a complex signalling network, but only few components have been identified so far. Gene-expression profiling revealed a >100-fold increase in the levels of the transcription factor and putative tumour suppressor gene TGFβ-stimulated clone 22 (TSC22D1) in BRAF(E600)-induced senescence, in both human fibroblasts and melanocytes. Only the short TSC22D1 transcript was upregulated, whereas the abundance of the large protein variant was suppressed by proteasomal degradation. The TSC22D1 protein variants, in complex with their dimerization partner TSC22 homologue gene 1 (THG1), exerted opposing functions, as selective depletion of the short form, or conversely, overexpression of the large variant, resulted in abrogation of OIS. This was accompanied by the suppression of several inflammatory factors and p15(INK4B), with TSC22D1 acting as a critical effector of C/EBPβ. Our results demonstrate that the differential regulation of antagonistic TSC22D1 variants is required for the establishment of OIS and suggest distinct contributions of TSC22 family members to the progression of BRAF(E600)-driven neoplasia.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology

UniBE Contributor:

Germann, Markus, Cecchini, Marco Giovanni




Nature Publishing Group




Factscience Import

Date Deposited:

04 Oct 2013 14:20

Last Modified:

05 Dec 2022 14:05

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URI: (FactScience: 211849)

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