Functionalization of PAMAM dendrimers with nitronyl nitroxide radicals as models for the outer-sphere relaxation in dentritic potential MRI contrast agents

Francese, Giancarlo; Dunand, Frank A.; Loosli, Claudia; Merbach, André E.; Decurtins, Silvio (2003). Functionalization of PAMAM dendrimers with nitronyl nitroxide radicals as models for the outer-sphere relaxation in dentritic potential MRI contrast agents. Magnetic resonance in chemistry, 41(2), pp. 81-83. Wiley Heyden 10.1002/mrc.1151

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PAMAM dendrimers functionalized with nitronyl nitroxide radicals were characterized. Quantitative determination of substitution with radicals was performed using EPR and electrochemical methods. The study of the 1H NMR relaxation of the surrounding water showed how the outer-sphere contribution to the relaxivity may be limited by the presence of the dendrimer core.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP)

UniBE Contributor:

Loosli, Claudia, Decurtins, Silvio

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

0749-1581

Publisher:

Wiley Heyden

Language:

English

Submitter:

Silvio Decurtins

Date Deposited:

20 May 2015 10:24

Last Modified:

05 Dec 2022 14:46

Publisher DOI:

10.1002/mrc.1151

BORIS DOI:

10.7892/boris.68533

URI:

https://boris.unibe.ch/id/eprint/68533

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