Hirtz, C.; Leumann, Christian (2003). Synthetic studies towards a novel, chemical stable, abasic site analogue of DNA. Nucleosides, nucleotides & nucleic acids, 22(5-8), pp. 1203-1206. Taylor & Francis 10.1081/NCN-120022836
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We synthesized the phosphinate 7 via photoaddition of methanol to the alpha, beta unsaturated deoxyribono lactone as the key step, followed by an Arbusov reaction for the introduction of phosphorous. Precursor 7 serves for the synthesis and incorporation into DNA of a novel chemically stable abasic site analogue that might act as an inhibitor for DNA glycosylases
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
UniBE Contributor: |
Leumann, Christian |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry |
ISSN: |
1525-7770 |
Publisher: |
Taylor & Francis |
Language: |
English |
Submitter: |
Christian Leumann |
Date Deposited: |
19 May 2015 09:20 |
Last Modified: |
05 Dec 2022 14:46 |
Publisher DOI: |
10.1081/NCN-120022836 |
PubMed ID: |
14565380 |
Additional Information: |
Notes: Department of Chemistry and Biochemistry, University of Bern, Bern, SwitzerlandFAU - Hirtz, Caroline |
Uncontrolled Keywords: |
abasic analogue chemical synthesis chemistry Deoxyribose DNA DNA Glycosylases DNA Repair glycosylase Indicators and Reagents OLIGODEOXYRIBONUCLEOTIDES Phosphines site synthesis |
BORIS DOI: |
10.7892/boris.68565 |
URI: |
https://boris.unibe.ch/id/eprint/68565 |
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