Synthetic studies towards a novel, chemical stable, abasic site analogue of DNA

Hirtz, C.; Leumann, Christian (2003). Synthetic studies towards a novel, chemical stable, abasic site analogue of DNA. Nucleosides, nucleotides & nucleic acids, 22(5-8), pp. 1203-1206. Taylor & Francis 10.1081/NCN-120022836

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We synthesized the phosphinate 7 via photoaddition of methanol to the alpha, beta unsaturated deoxyribono lactone as the key step, followed by an Arbusov reaction for the introduction of phosphorous. Precursor 7 serves for the synthesis and incorporation into DNA of a novel chemically stable abasic site analogue that might act as an inhibitor for DNA glycosylases

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Leumann, Christian

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

1525-7770

Publisher:

Taylor & Francis

Language:

English

Submitter:

Christian Leumann

Date Deposited:

19 May 2015 09:20

Last Modified:

19 May 2015 09:20

Publisher DOI:

10.1081/NCN-120022836

PubMed ID:

14565380

Additional Information:

Notes: Department of Chemistry and Biochemistry, University of Bern, Bern, SwitzerlandFAU - Hirtz, Caroline

Uncontrolled Keywords:

abasic analogue chemical synthesis chemistry Deoxyribose DNA DNA Glycosylases DNA Repair glycosylase Indicators and Reagents OLIGODEOXYRIBONUCLEOTIDES Phosphines site synthesis

BORIS DOI:

10.7892/boris.68565

URI:

https://boris.unibe.ch/id/eprint/68565

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