Häberli, A.; Mayer, Alain; Leumann, Christian (2003). Pyrrolidino-DNA. Nucleosides, nucleotides & nucleic acids, 22(5-8), pp. 1187-1189. Taylor & Francis 10.1081/NCN-120022832
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We synthesized pyrrolidino-C-nucleosides, incorporated them into oligodeoxynucleotides and investigated their pairing properties. The thermal duplex and triplex stabilities were measured. While triplex formation is destabilized in the case of pyrrolidino-pseudo-U and -T, pyrrolidino-pseudo-iso-C leads to an increase of the Tm value for third strand dissociation. Duplexes are destabilized with all pyrrolidino-C-nucleosides
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
UniBE Contributor: |
Mayer, Alain, Leumann, Christian |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry |
ISSN: |
1525-7770 |
Publisher: |
Taylor & Francis |
Language: |
English |
Submitter: |
Christian Leumann |
Date Deposited: |
19 May 2015 09:40 |
Last Modified: |
05 Dec 2022 14:46 |
Publisher DOI: |
10.1081/NCN-120022832 |
PubMed ID: |
14565376 |
Additional Information: |
Notes: Department of Chemistry and Biochemistry, University of Bern, Bern, SwitzerlandFAU - Haberli, Adrian |
Uncontrolled Keywords: |
analogs & derivatives chemical synthesis chemistry Cytosine DNA duplex DUPLEXES Indicators and Reagents Kinetics Oligodeoxynucleotides OLIGODEOXYRIBONUCLEOTIDES PAIRING PROPERTIES properties Pyrrolidines pyrrolidino-DNA stability thermal Thermodynamics Triplex Uracil |
BORIS DOI: |
10.7892/boris.68566 |
URI: |
https://boris.unibe.ch/id/eprint/68566 |
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