Pyrrolidino-DNA

Häberli, A.; Mayer, Alain; Leumann, Christian (2003). Pyrrolidino-DNA. Nucleosides, nucleotides & nucleic acids, 22(5-8), pp. 1187-1189. Taylor & Francis 10.1081/NCN-120022832

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We synthesized pyrrolidino-C-nucleosides, incorporated them into oligodeoxynucleotides and investigated their pairing properties. The thermal duplex and triplex stabilities were measured. While triplex formation is destabilized in the case of pyrrolidino-pseudo-U and -T, pyrrolidino-pseudo-iso-C leads to an increase of the Tm value for third strand dissociation. Duplexes are destabilized with all pyrrolidino-C-nucleosides

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Mayer, Alain and Leumann, Christian

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

1525-7770

Publisher:

Taylor & Francis

Language:

English

Submitter:

Christian Leumann

Date Deposited:

19 May 2015 09:40

Last Modified:

19 May 2015 09:40

Publisher DOI:

10.1081/NCN-120022832

PubMed ID:

14565376

Additional Information:

Notes: Department of Chemistry and Biochemistry, University of Bern, Bern, SwitzerlandFAU - Haberli, Adrian

Uncontrolled Keywords:

analogs & derivatives chemical synthesis chemistry Cytosine DNA duplex DUPLEXES Indicators and Reagents Kinetics Oligodeoxynucleotides OLIGODEOXYRIBONUCLEOTIDES PAIRING PROPERTIES properties Pyrrolidines pyrrolidino-DNA stability thermal Thermodynamics Triplex Uracil

BORIS DOI:

10.7892/boris.68566

URI:

https://boris.unibe.ch/id/eprint/68566

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