Häberli, A.; Leumann, Christian (2002). DNA binding properties of oligodeoxynucleotides containing pyrrolidino C-nucleosides. Organic letters, 4(19), pp. 3275-3278. American Chemical Society 10.1021/ol026537u
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We have incorporated pyrrolidino-C-nucleosides (pyrrolidino-pseudonucleosides) containing the base uracil and N-1-methyl uracil into oligodeoxynucleotides and compared their thermal duplex and triplex stabilities with unmodified or pseudouridine-containing oligodeoxynucleotides. We find relative destabilizations of triplex formation by ca. -13 to -1 degrees C per modification (relative to thymidine) in a strongly sequence dependent mode. Duplex formation is less destabilizing and more homogeneous with -4 to -2 degrees C per modification
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
UniBE Contributor: |
Leumann, Christian |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry |
ISSN: |
1523-7060 |
Publisher: |
American Chemical Society |
Language: |
English |
Submitter: |
Christian Leumann |
Date Deposited: |
19 May 2015 10:51 |
Last Modified: |
05 Dec 2022 14:47 |
Publisher DOI: |
10.1021/ol026537u |
PubMed ID: |
12227767 |
Uncontrolled Keywords: |
base binding C-nucleosides DNA duplex DUPLEXES Oligodeoxynucleotides properties pyrrolidino-DNA stability thermal thymidine Triplex Uracil |
BORIS DOI: |
10.7892/boris.68582 |
URI: |
https://boris.unibe.ch/id/eprint/68582 |
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