DNA triple-helix formation at pyrimidine-purine inversion sites

Parel, S. P.; Marfurt, J.; Leumann, Christian (2001). DNA triple-helix formation at pyrimidine-purine inversion sites. Nucleosides, nucleotides & nucleic acids, 20(4-7), pp. 411-417. Taylor & Francis 10.1081/NCN-100002315

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A systematic investigation of a series of triplex forming oligonucleotides (TFOs) containing alpha- and beta-thymidine, alpha- and beta-N7-hypoxanthine, and alpha- and beta- N7 and N9 aminopurine nucleosides, designed to bind to T-A inversion sites in DNA target sequences was performed. Data obtained from gel mobility assays indicate that t-A recognition in the antiparallel triple-helical binding motif is possible if the nucleoside alpha N9-aminopurine is used opposite to the inversion site in the TFO.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Leumann, Christian

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

1525-7770

Publisher:

Taylor & Francis

Language:

English

Submitter:

Christian Leumann

Date Deposited:

19 May 2015 14:05

Last Modified:

19 May 2015 14:05

Publisher DOI:

10.1081/NCN-100002315

PubMed ID:

11563056

Uncontrolled Keywords:

aminopurine antiparallel binding data DNA gel mobility inversion motif nucleoside nucleosides oligonucleotide Oligonucleotides recognition site triple helix TRIPLE-HELIX FORMATION Triplex

BORIS DOI:

10.7892/boris.68586

URI:

https://boris.unibe.ch/id/eprint/68586

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