Parel, S. P.; Marfurt, J.; Leumann, Christian (2001). DNA triple-helix formation at pyrimidine-purine inversion sites. Nucleosides, nucleotides & nucleic acids, 20(4-7), pp. 411-417. Taylor & Francis 10.1081/NCN-100002315
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A systematic investigation of a series of triplex forming oligonucleotides (TFOs) containing alpha- and beta-thymidine, alpha- and beta-N7-hypoxanthine, and alpha- and beta- N7 and N9 aminopurine nucleosides, designed to bind to T-A inversion sites in DNA target sequences was performed. Data obtained from gel mobility assays indicate that t-A recognition in the antiparallel triple-helical binding motif is possible if the nucleoside alpha N9-aminopurine is used opposite to the inversion site in the TFO.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
UniBE Contributor: |
Leumann, Christian |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry |
ISSN: |
1525-7770 |
Publisher: |
Taylor & Francis |
Language: |
English |
Submitter: |
Christian Leumann |
Date Deposited: |
19 May 2015 14:05 |
Last Modified: |
05 Dec 2022 14:47 |
Publisher DOI: |
10.1081/NCN-100002315 |
PubMed ID: |
11563056 |
Uncontrolled Keywords: |
aminopurine antiparallel binding data DNA gel mobility inversion motif nucleoside nucleosides oligonucleotide Oligonucleotides recognition site triple helix TRIPLE-HELIX FORMATION Triplex |
BORIS DOI: |
10.7892/boris.68586 |
URI: |
https://boris.unibe.ch/id/eprint/68586 |
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