Häberli, A.; Leumann, Christian (2001). Synthesis of pyrrolidine C-nucleosides via Heck reaction. Organic letters, 3(3), pp. 489-492. American Chemical Society 10.1021/ol007029s
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A novel method for the synthesis of pyrrolidine C-nucleosides has been developed. The key step of the synthesis is the palladium(0)-mediated coupling of a disubstituted N-protected 2-pyrroline and 5-iodouracil. C-Nucleoside 14 and its N-methyl derivative 15 can easily be converted to the corresponding phosphoramidite building blocks for DNA synthesis
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
UniBE Contributor: |
Leumann, Christian |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry |
ISSN: |
1523-7060 |
Publisher: |
American Chemical Society |
Language: |
English |
Submitter: |
Christian Leumann |
Date Deposited: |
19 May 2015 13:22 |
Last Modified: |
05 Dec 2022 14:47 |
Publisher DOI: |
10.1021/ol007029s |
Uncontrolled Keywords: |
BUILDING-BLOCKS C-nucleosides DNA phosphoramidite pyrrolidino-DNA synthesis |
BORIS DOI: |
10.7892/boris.68590 |
URI: |
https://boris.unibe.ch/id/eprint/68590 |
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