Differential spatial and structural organization of the X chromosome underlies dosage compensation in C. elegans.

Sharma, Rahul; Jost, Daniel; Kind, Jop; Gómez-Saldivar, Georgina; van Steensel, Bas; Askjaer, Peter; Vaillant, Cédric; Meister, Pierre (2014). Differential spatial and structural organization of the X chromosome underlies dosage compensation in C. elegans. Genes & development, 28(23), pp. 2591-2596. Cold Spring Harbor Laboratory Press 10.1101/gad.248864.114

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The adjustment of X-linked gene expression to the X chromosome copy number (dosage compensation [DC]) has been widely studied as a model of chromosome-wide gene regulation. In Caenorhabditis elegans, DC is achieved by twofold down-regulation of gene expression from both Xs in hermaphrodites. We show that in males, the single X chromosome interacts with nuclear pore proteins, while in hermaphrodites, the DC complex (DCC) impairs this interaction and alters X localization. Our results put forward a structural model of DC in which X-specific sequences locate the X chromosome in transcriptionally active domains in males, while the DCC prevents this in hermaphrodites.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Cell Biology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Sharma, Rahul and Meister, Pierre

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

0890-9369

Publisher:

Cold Spring Harbor Laboratory Press

Language:

English

Submitter:

Pierre Meister

Date Deposited:

07 May 2015 10:56

Last Modified:

15 Jan 2016 13:04

Publisher DOI:

10.1101/gad.248864.114

PubMed ID:

25452271

BORIS DOI:

10.7892/boris.68766

URI:

https://boris.unibe.ch/id/eprint/68766

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