Increased periodontal inflammation in women with preterm premature rupture of membranes

Stadelmann, Pascale; Eick, Sigrun; Salvi, Giovanni Edoardo; Surbek, Daniel; Mohr, Stefan; Bürgin, Walter Bruno; Ramseier, Christoph Andreas; Sculean, Anton (2015). Increased periodontal inflammation in women with preterm premature rupture of membranes. Clinical oral investigations, 19(6), pp. 1537-1546. Springer 10.1007/s00784-014-1371-6

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OBJECTIVES To evaluate possible differences in periodontal inflammatory, microbiological and clinical parameters between women with preterm premature rupture of membranes (PPROM) and controls with uncomplicated pregnancies. MATERIALS AND METHODS Fifty-six women (32 test (PPROM) and 24 controls (uncomplicated pregnancies)) were examined at three time-points (T1: gestational weeks 20-35, T2: within 48 h after parturition, T3: 4-6 weeks after parturition). The examinations included assessment of the Periodontal Screening Index, collection of gingival crevicular fluid (GCF) and subgingival as well as vaginal bacterial sampling. RESULTS Periodontal inflammation was found to be higher in the test compared with the control group (p < 0.05) and decreased over time in both groups (p < 0.05). Microbiological outcomes showed no intergroup differences (p > 0.05) in prevalence of bacteria, but a decrease in subgingival periodontopathogens from T1 to T2 in the test group (p < 0.05) was observed. Interleukin (IL)-1β levels in GCF at T2 were not different between groups (p > 0.05). In women with PPROM, GCF levels of IL-8 (p < 0.05) and C-reactive protein (p < 0.05) were lower and IL-10 levels higher (p < 0.05) compared with controls. CONCLUSIONS Periodontal inflammation is elevated during pregnancy and seems to be more pronounced in women with PPROM. CLINICAL RELEVANCE The findings of the present study revealed an association between periodontal inflammation and PPROM, thus emphasizing the importance of optimizing self-performed oral hygiene in pregnant women.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > School of Dental Medicine, Research
04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology
04 Faculty of Medicine > School of Dental Medicine
04 Faculty of Medicine > School of Dental Medicine > Department of Preventive, Restorative and Pediatric Dentistry
04 Faculty of Medicine > School of Dental Medicine > School of Dental Medicine, Periodontics Research
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Stadelmann, Pascale; Eick, Sigrun; Salvi, Giovanni Edoardo; Surbek, Daniel; Mohr, Stefan; Bürgin, Walter Bruno; Ramseier, Christoph Andreas and Sculean, Anton

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1432-6981

Publisher:

Springer

Language:

English

Submitter:

Nathalie Ursula Becher

Date Deposited:

12 May 2015 16:37

Last Modified:

12 Feb 2016 10:24

Publisher DOI:

10.1007/s00784-014-1371-6

PubMed ID:

25420538

Uncontrolled Keywords:

PPROM, Periodontal inflammation, Periodontopathogenic bacteria, Gingival crevicular fluid, Inflammatory mediators, Adverse pregnancy outcomes

BORIS DOI:

10.7892/boris.68907

URI:

https://boris.unibe.ch/id/eprint/68907

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