Fetal megacystis: experience of a single tertiary center in Switzerland over 20 years

Müller Brochut, Anne-Claude; Thomann, Daniel; Kluwe, Wolfram; Di Naro, Edoardo; Kuhn, Annette; Raio, Luigi (2014). Fetal megacystis: experience of a single tertiary center in Switzerland over 20 years. Fetal diagnosis and therapy, 36(3), pp. 215-222. Karger 10.1159/000358300

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OBJECTIVES Megacystis (MC) is rare and often associated with other structural and chromosomal anomalies. In euploid cases with early oligohydramnios, prognosis is poor mainly due to pulmonary hypoplasia and renal damage. We report our experience of the past 20 years. METHODS A retrospective review of cases with prenatally diagnosed MC was performed. Complete prenatal as well as postnatal medical records from 1989 to 2009 were reviewed focusing on diagnostic precision, fetal interventions [vesicocentesis (VC), vesicoamniotic shunt (VAS)], short- and long-term outcome, and potential prognostic factors. RESULTS 68 cases were included. Follow-up was available in 54 cases (9 girls and 45 boys including 3 cases with aneuploidy). We found 39 isolated MC at sonography (5 girls and 34 boys). 24 fetuses with isolated MC underwent VC and VAS at 19.6 ± 6.3 and 20 ± 4.9 weeks of gestation, respectively. Survival rate was higher in male than in female fetuses (51 vs. 33%). Renal problems occurred in 4/14 prenatally treated fetuses and in 1/10 when cases with prune belly syndrome (PBS) were excluded from the analysis. CONCLUSIONS Our study shows that a careful selection of cases with MC excluding fetuses with PBS and early treatment has still the potential to improve outcome.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Müller Brochut, Anne-Claude; Kuhn, Annette and Raio, Luigi


600 Technology > 610 Medicine & health








Nathalie Ursula Becher

Date Deposited:

12 May 2015 17:05

Last Modified:

11 Nov 2015 09:25

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