Immune-Deficient Drosophila melanogaster: A Model for the Innate Immune Response to Human Fungal Pathogens

Alarco, Anne-Marie; Marcil, Anne; Chen, Jian; Suter, Beat; Thomas, David; Whiteway, Malcolm (2004). Immune-Deficient Drosophila melanogaster: A Model for the Innate Immune Response to Human Fungal Pathogens. Journal of immunology, 172(9), pp. 5622-5628. American Association of Immunologists 10.4049/jimmunol.172.9.5622

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We explored the host-pathogen interactions of the human opportunistic fungus Candida albicans using Drosophila melanogaster. We established that a Drosophila strain devoid of functional Toll receptor is highly susceptible to the human pathogen C. albicans. Using this sensitive strain, we have been able to show that a set of specific C. albicans mutants of different virulence in mammalian infection models are also impaired in virulence in Drosophila and remarkably display the same rank order of virulence. This immunodeficient insect model also revealed virulence properties undetected in an immunocompetent murine model of infection. The genetic systems available in both host and pathogen will enable the identification of host-specific components and C. albicans genes involved in the host-fungal interplay.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Cell Biology

UniBE Contributor:

Suter, Beat

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

0022-1767

Publisher:

American Association of Immunologists

Language:

English

Submitter:

Beat Suter

Date Deposited:

26 May 2015 15:51

Last Modified:

26 May 2015 15:51

Publisher DOI:

10.4049/jimmunol.172.9.5622

BORIS DOI:

10.7892/boris.68943

URI:

https://boris.unibe.ch/id/eprint/68943

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