The swiss transplant cohort study: lessons from the first 6 years.

Berger, Christoph; Bochud, Pierre-Yves; Boggian, Katja; Cusini, Alexia; Egli, Adrian; Garzoni, Christian; Hirsch, Hans H; Hoffmann, Matthias; Khanna, Nina; Manuel, Oriol; Meylan, Pascal; Nadal, David; van Delden, Christian; Weisser, Maja; Mueller, Nicolas J (2015). The swiss transplant cohort study: lessons from the first 6 years. Current infectious disease reports, 17(6), p. 486. Current Science 10.1007/s11908-015-0486-5

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Prospective cohort studies significantly contribute to answering specific research questions in a defined population. Since 2008, the Swiss Transplant Cohort Study (STCS) systematically enrolled >95 % of all transplant recipients in Switzerland, collecting predefined data at determined time points. Designed as an open cohort, the STCS has included >3900 patients to date, with a median follow-up of 2.96 years (IQR 1.44-4.73). This review highlights some relevant findings in the field of transplant-associated infections gained by the STCS so far. Three key general aspects have crystallized: (i) Well-run cohort studies are a powerful tool to conduct genetic studies, which are crucially dependent on a meticulously described phenotype. (ii) Long-term real-life observations are adding a distinct layer of information that cannot be obtained during randomized studies. (iii) The systemic collection of data, close interdisciplinary collaboration, and continuous analysis of some key outcome data such as infectious diseases endpoints can improve patient care.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Cusini, Alexia

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1523-3847

Publisher:

Current Science

Language:

English

Submitter:

Annelies Luginbühl

Date Deposited:

21 May 2015 14:58

Last Modified:

19 Oct 2015 11:05

Publisher DOI:

10.1007/s11908-015-0486-5

PubMed ID:

25916997

URI:

https://boris.unibe.ch/id/eprint/68975

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