IGRA-positive patients and interferon-gamma/interleukin-2 signatures: can the Fluorospot assay provide further information?

Bittel, Pascal; Mayor, Désirée; Iseli, P; Bodmer, T; Suter-Riniker, Franziska (2014). IGRA-positive patients and interferon-gamma/interleukin-2 signatures: can the Fluorospot assay provide further information? Infection, 42(3), pp. 539-543. Springer-Medizin-Verlag 10.1007/s15010-014-0588-2

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A goal of testing for latent tuberculosis (TB) infection is to identify individuals who are at increased risk for the development of active TB. No laboratory tool is currently available to distinguish between individuals in the process of progressing from latent TB infection towards active disease and those who are not. Determination of the interferon-gamma and interleukin-2 T cell signature might provide an additional and rapid tool to evaluate treatment necessity and clinical management of a patient. Here, we present three cases of interferon-gamma release assay-positive patients with differing interferon-gamma and interleukin-2 signatures when analyzed by the Fluorospot assay.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > VIM
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Clinical Microbiology

UniBE Contributor:

Bittel, Pascal; Mayor, Désirée and Suter, Franziska Marta

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0300-8126

Publisher:

Springer-Medizin-Verlag

Language:

English

Submitter:

Franziska Marta Suter

Date Deposited:

09 Jun 2015 09:40

Last Modified:

06 Nov 2015 10:59

Publisher DOI:

10.1007/s15010-014-0588-2

PubMed ID:

24477887

BORIS DOI:

10.7892/boris.69186

URI:

https://boris.unibe.ch/id/eprint/69186

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