Clinical significance of the CCR5delta32 allele in hepatitis C.

Morard, Isabelle; Clément, Sophie; Calmy, Alexandra; Mangia, Alessandra; Cerny, Andrea; De Gottardi, Andrea; Gorgievski, Meri; Heim, Markus; Malinverni, Raffaele; Moradpour, Darius; Müllhaupt, Beat; Semela, David; Pascarella, Stéphanie; Bochud, Pierre-Yves; Negro, Franco (2014). Clinical significance of the CCR5delta32 allele in hepatitis C. PLoS ONE, 9(9), e106424. Public Library of Science 10.1371/journal.pone.0106424

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BACKGROUND The CCR5 receptor, expressed on Th1 cells, may influence clinical outcomes of HCV infection. We explored a possible link between a CCR5 32-base deletion (CCR5delta32), resulting in the expression of a non-functioning receptor, and clinical outcomes of HCV infection. METHODS CCR5 and HCV-related phenotypes were analysed in 1,290 chronically infected patients and 160 patients with spontaneous clearance. RESULTS Carriage of the CCR5delta32 allele was observed in 11% of spontaneous clearers compared to 17% of chronically infected patients (OR = 0.59, 95% CI interval 0.35-0.99, P = 0.047). Carriage of this allele also tended to be observed more frequently among patients with liver inflammation (19%) compared to those without inflammation (15%, OR = 1.38, 95% CI interval 0.99-1.95, P = 0.06). The CCR5delta32 was not associated with sustained virological response (P = 0.6), fibrosis stage (P = 0.8), or fibrosis progression rate (P = 0.4). CONCLUSIONS The CCR5delta32 allele appears to be associated with a decreased rate of spontaneous HCV eradication, but not with hepatitis progression or response to antiviral therapy.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

De Gottardi, Andrea and Gorgievski, Meri

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1932-6203

Publisher:

Public Library of Science

Language:

English

Submitter:

Meri Gorgievski

Date Deposited:

01 Jun 2015 09:59

Last Modified:

01 Jun 2015 09:59

Publisher DOI:

10.1371/journal.pone.0106424

PubMed ID:

25191700

BORIS DOI:

10.7892/boris.69230

URI:

https://boris.unibe.ch/id/eprint/69230

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