Prognostic value of matrix metalloproteinases in oral squamous cell carcinoma

Mishev, Georgi; Deliverska, Elitsa; Hlushchuk, Ruslan; Velinov, Nikolay; Aebersold, Daniel; Weinstein, Felix; Djonov, Valentin (2014). Prognostic value of matrix metalloproteinases in oral squamous cell carcinoma. Biotechnology & biotechnological equipment, 28(6), pp. 1138-1149. Taylor & Francis 10.1080/13102818.2014.967510

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The aim of this study was to investigate whether there is a correlation between the expressions of four matrix metalloproteinases (MMPs): MMP-2, MMP-7, MMP-9 and MMP-13, and the TNM (tumour-node-metastasis) stages of oral squamous cell carcinoma (OSCC); and to explore the implication of these MMPs in OSCC dissemination. Samples from 61 patients diagnosed with oropharyngeal tumour were studied by immunohistochemistry against MMP-2, MMP-7, MMP-9 and MMP-13. The assessment of immunoreactivity was semi-quantitative. The results showed that MMP-2 and MMP-9 had similar expression patterns in the tumour cells with no changes in the immunoreactivity during tumour progression. MMP-9 always had the highest expression, whereas that of MMP-2 was moderate. MMP-7 showed a significant decrease in expression levels during tumour evolution. MMP-13 had constant expression levels within stage T2 and T3, but showed a remarkable decline in immunoreactivity in stage T4. No significant differences in the MMPs immunoreactivity between tumour cells and stroma were observed. Although strong evidence for the application of MMPs as reliable predictive markers for node metastasis was not acquired, we believe that combining patients' MMPs expression intensity and clinical features may improve the diagnosis and prognosis. Strong evidence for the application of MMPs as reliable predictive markers for node metastasis was not acquired. Application of MMPs as prognostic indicators for the malignancy potential of OSCC might be considered in every case of tumour examination. We believe that combining patients' MMPs expression intensity and clinical features may improve the process of making diagnosis and prognosis.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology

UniBE Contributor:

Hlushchuk, Ruslan; Velinov, Nikolay; Aebersold, Daniel; Weinstein, Felix and Djonov, Valentin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1310-2818

Publisher:

Taylor & Francis

Language:

English

Submitter:

Beatrice Scheidegger

Date Deposited:

10 Jun 2015 10:15

Last Modified:

07 Nov 2017 16:36

Publisher DOI:

10.1080/13102818.2014.967510

PubMed ID:

26019601

Uncontrolled Keywords:

matrix metalloproteinase, oropharyngeal squamous cell carcinoma, tumour progression

BORIS DOI:

10.7892/boris.69258

URI:

https://boris.unibe.ch/id/eprint/69258

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