Pneumocystis carinii pneumonia during immunosuppressive therapy for antineutrophil cytoplasmic autoantibody-positive vasculitis.

Huynh-Do, Uyen; Gantenbein, H; Binswanger, U (1995). Pneumocystis carinii pneumonia during immunosuppressive therapy for antineutrophil cytoplasmic autoantibody-positive vasculitis. Archives of internal medicine, 155(8), pp. 872-874. American Medical Association 10.1001/archinte.1995.00430080122016

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We describe two human immunodeficiency virus-negative patients who developed Pneumocystis carinii pneumonia (PCP) during immunosuppressive therapy for antineutrophil cytoplasmic autoantibody-positive vasculitis and review the literature regarding the pathogenesis and frequency of PCP. The recent application of DNA amplification techniques suggests that PCP developing in immunocompromised individuals does not necessarily result from reactivation of a dormant focus, but may arise as de novo infection after exposure to an exogenous source of P carinii. In addition, several reports about clusters of PCP cases raise concern about the risk of a nosocomial transmission of P carinii. Therefore, PCP should be added to the list of bronchopulmonary complications in patients with antineutrophil cytoplasmic autoantibody-positive vasculitis who are receiving long-term steroid therapy.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension

UniBE Contributor:

Huynh-Do, Uyen

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0003-9926

Publisher:

American Medical Association

Language:

English

Submitter:

Uyen Huynh-Do

Date Deposited:

17 Jun 2015 09:52

Last Modified:

17 Jun 2015 09:52

Publisher DOI:

10.1001/archinte.1995.00430080122016

PubMed ID:

7717797

BORIS DOI:

10.7892/boris.69631

URI:

https://boris.unibe.ch/id/eprint/69631

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