Gakis, Georgios; Morgan, Todd M; Efstathiou, Jason A; Keegan, Kirk A; Mischinger, Johannes; Todenhoefer, Tilman; Schubert, Tina; Zaid, Harras B; Hrbacek, Jan; Ali-El-Dein, Bedeir; Clayman, Rebecca H; Galland, Sigolene; Olugbade, Kola; Rink, Michael; Fritsche, Hans-Martin; Burger, Maximilian; Chang, Sam S; Babjuk, Marko; Thalmann, George; Stenzl, Arnulf; ... (2016). Prognostic factors and outcomes in primary urethral cancer: results from the international collaboration on primary urethral carcinoma. World journal of urology, 34(1), pp. 97-103. Springer 10.1007/s00345-015-1583-7
|
Text
Thalmann_World J Urol_Prognostic factors.pdf - Published Version Available under License Publisher holds Copyright. Download (431kB) | Preview |
PURPOSE
To evaluate risk factors for survival in a large international cohort of patients with primary urethral cancer (PUC).
METHODS
A series of 154 patients (109 men, 45 women) were diagnosed with PUC in ten referral centers between 1993 and 2012. Kaplan-Meier analysis with log-rank test was used to investigate various potential prognostic factors for recurrence-free (RFS) and overall survival (OS). Multivariate models were constructed to evaluate independent risk factors for recurrence and death.
RESULTS
Median age at definitive treatment was 66 years (IQR 58-76). Histology was urothelial carcinoma in 72 (47 %), squamous cell carcinoma in 46 (30 %), adenocarcinoma in 17 (11 %), and mixed and other histology in 11 (7 %) and nine (6 %), respectively. A high degree of concordance between clinical and pathologic nodal staging (cN+/cN0 vs. pN+/pN0; p < 0.001) was noted. For clinical nodal staging, the corresponding sensitivity, specificity, and overall accuracy for predicting pathologic nodal stage were 92.8, 92.3, and 92.4 %, respectively. In multivariable Cox-regression analysis for patients staged cM0 at initial diagnosis, RFS was significantly associated with clinical nodal stage (p < 0.001), tumor location (p < 0.001), and age (p = 0.001), whereas clinical nodal stage was the only independent predictor for OS (p = 0.026).
CONCLUSIONS
These data suggest that clinical nodal stage is a critical parameter for outcomes in PUC.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology |
UniBE Contributor: |
Thalmann, George |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0724-4983 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Katharina Morgenegg |
Date Deposited: |
24 Jun 2015 08:24 |
Last Modified: |
05 Dec 2022 14:47 |
Publisher DOI: |
10.1007/s00345-015-1583-7 |
PubMed ID: |
25981402 |
BORIS DOI: |
10.7892/boris.69763 |
URI: |
https://boris.unibe.ch/id/eprint/69763 |
Actions (login required)
 |
Edit item |